Assay Detail
Binding
CHEMBL748433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60656 | — | — | 1 | 6.02 |
| CHEMBL58416 | — | — | 1 | 6.00 |
| CHEMBL291780 | — | — | 1 | 5.92 |
| CHEMBL293142 | — | — | 1 | 5.82 |
| CHEMBL144540 | — | — | 1 | 5.77 |
| CHEMBL291442 | — | — | 1 | 5.55 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.55 |
| CHEMBL274525 | ABT-418 | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60656 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL58416 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL291780 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL293142 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL144540 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL291442 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3 | NICOTINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL274525 | ABT-418 | IC50 | = | 44000.0 | nM | 4.36 |