Assay Detail
Binding
CHEMBL748438
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Binding affinity for muscarinic receptor site in rat hippocampus was determined using competitive radioligand binding assays employing [3H]OXO-M
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Isoarecolones and arecolones: selective central nicotinic agonists that cross the blood-brain barrier
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.66 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.40 |
| CHEMBL152775 | — | — | 1 | 5.86 |
| CHEMBL154329 | — | — | 1 | 5.78 |
| CHEMBL152310 | — | — | 1 | 5.72 |
| CHEMBL346802 | ARECOLON | — | 1 | 5.71 |
| CHEMBL346466 | — | — | 1 | 5.61 |
| CHEMBL154385 | — | — | 1 | 5.57 |
| CHEMBL153298 | — | — | 1 | 5.56 |
| CHEMBL152530 | — | — | 1 | 5.46 |
| CHEMBL156793 | — | — | 1 | 5.43 |
| CHEMBL157267 | — | — | 1 | 5.36 |
| CHEMBL152050 | — | — | 1 | 5.36 |
| CHEMBL265553 | — | — | 1 | 5.27 |
| CHEMBL154941 | — | — | 1 | 5.20 |
| CHEMBL351805 | — | — | 1 | - |
| CHEMBL3 | NICOTINE | 4.0 | 1 | - |
| CHEMBL439821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7303 | ARECOLINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL152775 | — | Ki | = | 1385.0 | nM | 5.86 |
| CHEMBL154329 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL152310 | — | Ki | = | 1885.0 | nM | 5.72 |
| CHEMBL346802 | ARECOLON | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL346466 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL154385 | — | Ki | = | 2690.0 | nM | 5.57 |
| CHEMBL153298 | — | Ki | = | 2730.0 | nM | 5.56 |
| CHEMBL152530 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL156793 | — | Ki | = | 3750.0 | nM | 5.43 |
| CHEMBL157267 | — | Ki | = | 4380.0 | nM | 5.36 |
| CHEMBL152050 | — | Ki | = | 4345.0 | nM | 5.36 |
| CHEMBL265553 | — | Ki | = | 5425.0 | nM | 5.27 |
| CHEMBL154941 | — | Ki | = | 6250.0 | nM | 5.20 |
| CHEMBL351805 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3 | NICOTINE | Ki | > | 5000.0 | nM | - |
| CHEMBL439821 | — | Ki | > | 5000.0 | nM | - |