Assay Detail
Binding
CHEMBL748442
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Inhibition of radioligand [3H]NMS binding to muscarinic receptor of rat brain
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.94 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111686 | — | — | 1 | 7.41 |
| CHEMBL2111684 | — | — | 1 | 5.13 |
| CHEMBL109124 | — | — | 1 | 4.94 |
| CHEMBL110319 | — | — | 1 | 4.84 |
| CHEMBL109160 | — | — | 1 | 4.83 |
| CHEMBL2008608 | — | — | 1 | 4.73 |
| CHEMBL322329 | — | — | 1 | 4.63 |
| CHEMBL38791 | — | — | 2 | 4.60 |
| CHEMBL3350264 | — | — | 1 | 4.58 |
| CHEMBL2111685 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111686 | — | Ki | = | 39.1 | nM | 7.41 |
| CHEMBL2111684 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL109124 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL110319 | — | Ki | = | 14400.0 | nM | 4.84 |
| CHEMBL109160 | — | Ki | = | 14700.0 | nM | 4.83 |
| CHEMBL2008608 | — | Ki | = | 18600.0 | nM | 4.73 |
| CHEMBL322329 | — | Ki | = | 23300.0 | nM | 4.63 |
| CHEMBL38791 | — | Ki | = | 25300.0 | nM | 4.60 |
| CHEMBL3350264 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL38791 | — | Ki | = | 46400.0 | nM | 4.33 |
| CHEMBL2111685 | — | Ki | = | 50300.0 | nM | 4.30 |