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Assay Detail

CHEMBL748547

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Ability to reverse Neuropeptide Y receptor type 1-induced inhibition of forskolin-induced inhibition of forskolin-stimulated cAMP
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 1 (CHEMBL4777)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists.
Hipskind PA, Lobb KL, Nixon JA, Britton TC, Bruns RF, Catlow J, Dieckman-McGinty DK, Gackenheimer SL, Gitter BD, Iyengar S, Schober DA, Simmons RM, Swanson S, Zarrinmayeh H, Zimmerman DM, Gehlert DR.
J Med Chem (1997) 40 : 3712 -3714
PubMed 9371234 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.74 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329536 1 8.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329536 Ki = 1.8 nM 8.74