Assay Detail
Binding
CHEMBL748558
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Binding affinity against PCP site of the NMDA Receptor using [3H]TCP radioligand
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and binding affinity of 2,3,3a,4,9,9a-hexahydro-9,4-(iminomethano)-1H-benz[f]indenes. Ligands for the PCP site of the NMDA receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.10 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.66 |
| CHEMBL125817 | — | — | 1 | 8.10 |
| CHEMBL122551 | — | — | 1 | 7.85 |
| CHEMBL123708 | — | — | 1 | 7.42 |
| CHEMBL124965 | — | — | 1 | 7.28 |
| CHEMBL341129 | — | — | 2 | 7.05 |
| CHEMBL122770 | — | — | 1 | 6.65 |
| CHEMBL126215 | — | — | 1 | 6.15 |
| CHEMBL445377 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL125817 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL122551 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL123708 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL124965 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL341129 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL122770 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL126215 | — | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL445377 | — | Ki | = | 1142.0 | nM | 5.94 |
| CHEMBL341129 | — | Ki | = | 1204.0 | nM | 5.92 |