Assay Detail
Binding
CHEMBL748573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [3H]-L-689,560 from rat cortical membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5,6,7,8-Tetrahydroquinolones as antagonists at the glycine site of the NMDA receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.17 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31741 | — | — | 1 | 8.70 |
| CHEMBL65327 | — | — | 1 | 7.70 |
| CHEMBL64010 | — | — | 1 | 7.24 |
| CHEMBL31661 | — | — | 1 | 6.77 |
| CHEMBL435378 | — | — | 1 | 5.46 |
| CHEMBL65983 | — | — | 1 | - |
| CHEMBL65930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31741 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL65327 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL64010 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL31661 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL435378 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL65983 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL65930 | — | IC50 | > | 100000.0 | nM | - |