Compound Detail
CHEMBL435378
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Basic Information
| ChEMBL ID | CHEMBL435378 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VPWTZJBXKSFWRP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
3.28
ALogP
3
HBA
2
HBD
53.4
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 3500.0 | nM | 5.46 | Compound was evaluated for its ability to displace [3H]-L-689,560 from rat corti... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00374-3 | Glutamate receptor ionotropic, NMDA 1 | 2 |
| - | 10.1016/0960-894X(95)00374-3 | Mus musculus | 2 |
Data from ChEMBL 36 via Core Engine