Assay Detail
Binding
CHEMBL748707
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Evaluated for its binding affinity towards Nicotinic acetylcholine receptor in rat brain homogenate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Lobeline: structure-affinity investigation of nicotinic acetylcholinergic receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.34 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | 2.0 | 1 | 8.40 |
| CHEMBL333898 | — | — | 1 | 8.30 |
| CHEMBL122425 | — | — | 1 | 6.96 |
| CHEMBL122317 | — | — | 1 | 6.63 |
| CHEMBL122676 | — | — | 1 | 6.52 |
| CHEMBL125511 | 8R-hydroxylobelane | — | 1 | 6.47 |
| CHEMBL339402 | — | — | 1 | 5.96 |
| CHEMBL124219 | — | — | 1 | 5.88 |
| CHEMBL433194 | — | — | 1 | 5.69 |
| CHEMBL332074 | — | — | 1 | 5.66 |
| CHEMBL121876 | — | — | 1 | 5.60 |
| CHEMBL50115 | — | — | 1 | 5.23 |
| CHEMBL331161 | — | — | 1 | 5.11 |
| CHEMBL122636 | — | — | 1 | - |
| CHEMBL122723 | — | — | 1 | - |
| CHEMBL120990 | — | — | 1 | - |
| CHEMBL122314 | — | — | 1 | - |
| CHEMBL333465 | LOBELANE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL333898 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL122425 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL122317 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL122676 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL125511 | 8R-hydroxylobelane | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL339402 | — | Ki | = | 1085.0 | nM | 5.96 |
| CHEMBL124219 | — | Ki | = | 1315.0 | nM | 5.88 |
| CHEMBL433194 | — | Ki | = | 2035.0 | nM | 5.69 |
| CHEMBL332074 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL121876 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL50115 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL331161 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL122636 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL122723 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL120990 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL122314 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL333465 | LOBELANE | Ki | > | 10000.0 | nM | - |