Assay Detail
Binding
CHEMBL748714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.89 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329536 | — | — | 1 | 9.12 |
| CHEMBL61532 | — | — | 1 | 8.77 |
| CHEMBL44246 | — | — | 1 | 8.34 |
| CHEMBL330223 | — | — | 1 | 8.22 |
| CHEMBL91462 | — | — | 1 | 8.15 |
| CHEMBL93535 | — | — | 1 | 7.80 |
| CHEMBL90717 | — | — | 1 | 7.77 |
| CHEMBL93375 | — | — | 1 | 7.75 |
| CHEMBL328532 | — | — | 1 | 7.57 |
| CHEMBL92679 | — | — | 1 | 7.54 |
| CHEMBL328541 | — | — | 1 | 7.52 |
| CHEMBL92148 | — | — | 1 | 7.39 |
| CHEMBL94292 | — | — | 1 | 7.37 |
| CHEMBL329224 | — | — | 1 | 7.01 |
| CHEMBL328460 | — | — | 1 | 6.82 |
| CHEMBL329786 | — | — | 1 | 6.40 |
| CHEMBL91738 | — | — | 1 | 6.16 |
| CHEMBL90574 | — | — | 1 | 6.03 |
| CHEMBL90605 | — | — | 1 | 6.01 |
| CHEMBL90369 | — | — | 1 | 5.92 |
| CHEMBL92685 | — | — | 1 | 5.89 |
| CHEMBL210900 | — | — | 1 | 5.89 |
| CHEMBL421549 | — | — | 1 | 5.64 |
| CHEMBL330066 | — | — | 1 | 5.49 |
| CHEMBL420613 | — | — | 1 | 5.28 |
| CHEMBL316291 | — | — | 1 | 5.15 |
| CHEMBL330703 | — | — | 1 | 5.11 |
| CHEMBL93324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329536 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL61532 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL44246 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL330223 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL91462 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL93535 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL90717 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL93375 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL328532 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL92679 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL328541 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL92148 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL94292 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL329224 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL328460 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL329786 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL91738 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL90574 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL90605 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL90369 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL92685 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL210900 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL421549 | — | Ki | = | 2310.0 | nM | 5.64 |
| CHEMBL330066 | — | Ki | = | 3230.0 | nM | 5.49 |
| CHEMBL420613 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL316291 | — | Ki | = | 7020.0 | nM | 5.15 |
| CHEMBL330703 | — | Ki | = | 7860.0 | nM | 5.11 |
| CHEMBL93324 | — | Ki | > | 100000.0 | nM | - |