Assay Detail
Binding
CHEMBL748740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against nicotinic acetylcholine receptor using [3H]epibatidine as radioligand in rat brain tissue
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and nicotinic receptor activity of a hydroxylated tropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.60 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.47 |
| CHEMBL421553 | — | — | 1 | 7.75 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL421553 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3 | NICOTINE | Ki | = | 27.0 | nM | 7.57 |