Assay Detail
Binding
CHEMBL748770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glycine from glycine site on the NMDA receptor.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.94 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.40 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | — | 1 | 6.68 |
| CHEMBL112386 | — | — | 1 | 6.20 |
| CHEMBL325124 | — | — | 1 | 5.90 |
| CHEMBL112193 | — | — | 1 | 5.83 |
| CHEMBL323414 | — | — | 1 | 5.54 |
| CHEMBL113270 | — | — | 1 | 5.41 |
| CHEMBL109207 | — | — | 1 | 5.34 |
| CHEMBL321171 | — | — | 1 | 5.13 |
| CHEMBL113107 | — | — | 1 | - |
| CHEMBL322734 | — | — | 1 | - |
| CHEMBL112431 | — | — | 1 | - |
| CHEMBL110799 | — | — | 1 | - |
| CHEMBL113588 | — | — | 1 | - |
| CHEMBL322354 | — | — | 1 | - |
| CHEMBL114498 | — | — | 1 | - |
| CHEMBL325557 | — | — | 1 | - |
| CHEMBL112014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL112386 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL325124 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL112193 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL323414 | — | Ki | = | 2850.0 | nM | 5.54 |
| CHEMBL113270 | — | Ki | = | 3920.0 | nM | 5.41 |
| CHEMBL109207 | — | Ki | = | 4580.0 | nM | 5.34 |
| CHEMBL321171 | — | Ki | = | 7350.0 | nM | 5.13 |
| CHEMBL113107 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL322734 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL112431 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL110799 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL113588 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL322354 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL114498 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL325557 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL112014 | — | Ki | > | 10000.0 | nM | - |