Compound Detail
CHEMBL112193
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL112193 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QVWOBHYWTYRGBS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
311.2
MW (Da)
3.63
ALogP
5
HBA
1
HBD
63.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | Ki | 5.83 | 5.83 | 1480.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 5.77 | 5.77 | 1710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 1480.0 | nM | 5.83 | Displacement of [3H]glycine from glycine site on the NMDA receptor. | 1382133 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 1710.0 | nM | 5.77 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA. | 1382133 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1382133 | 10.1021/jm00096a002 | Glutamate receptor ionotropic, AMPA | 1 |
| 1382133 | 10.1021/jm00096a002 | Glutamate receptor ionotropic, NMDA 1 | 1 |
Data from ChEMBL 36 via Core Engine