Assay Detail
Binding
CHEMBL748802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding activity against muscarinic receptor in rat brain using [3H]QNB as the radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.32 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73538 | — | — | 1 | 7.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.29 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73538 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 55.0 | nM | 7.26 |