Assay Detail
Binding
CHEMBL748833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.69 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311212 | — | — | 1 | 8.26 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 7.89 |
| CHEMBL312434 | — | — | 1 | 7.85 |
| CHEMBL308343 | — | — | 1 | 7.51 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311212 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL312434 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL308343 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 115.0 | nM | 6.94 |