Assay Detail
Binding
CHEMBL748835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.39 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78697 | — | — | 1 | 8.59 |
| CHEMBL309432 | — | — | 1 | 8.44 |
| CHEMBL311799 | — | — | 1 | 8.38 |
| CHEMBL79040 | — | — | 1 | 8.27 |
| CHEMBL80723 | — | — | 1 | 8.23 |
| CHEMBL81281 | — | — | 1 | 7.96 |
| CHEMBL309638 | — | — | 1 | 7.92 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 7.92 |
| CHEMBL311562 | — | — | 1 | 7.92 |
| CHEMBL309729 | — | — | 1 | 7.89 |
| CHEMBL311036 | — | — | 1 | 7.85 |
| CHEMBL311703 | — | — | 1 | 7.85 |
| CHEMBL79020 | — | — | 1 | 7.80 |
| CHEMBL81492 | — | — | 1 | 7.77 |
| CHEMBL311989 | — | — | 1 | 7.75 |
| CHEMBL442975 | — | — | 1 | 7.72 |
| CHEMBL81314 | — | — | 1 | 7.52 |
| CHEMBL23118 | — | — | 1 | 7.51 |
| CHEMBL79374 | — | — | 1 | 7.46 |
| CHEMBL311297 | — | — | 1 | 7.42 |
| CHEMBL23721 | — | — | 1 | 7.32 |
| CHEMBL23335 | — | — | 1 | 7.12 |
| CHEMBL309498 | — | — | 1 | 7.10 |
| CHEMBL311008 | — | — | 1 | 7.10 |
| CHEMBL280219 | — | — | 1 | 7.07 |
| CHEMBL309281 | — | — | 1 | 7.00 |
| CHEMBL276975 | — | — | 1 | 6.84 |
| CHEMBL23563 | — | — | 1 | 6.62 |
| CHEMBL311246 | — | — | 1 | 6.60 |
| CHEMBL79265 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78697 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL309432 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL311799 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL79040 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL80723 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL81281 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL309638 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL667 | ACETYLCHOLINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL311562 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL309729 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL311036 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL311703 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL79020 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL81492 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL311989 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL442975 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL81314 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL23118 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL79374 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL311297 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL23721 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL23335 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL309498 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL311008 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL280219 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL309281 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL276975 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL23563 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL311246 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL79265 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL9967 | PIRENZEPINE | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL82188 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL80917 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL78820 | — | IC50 | = | 4100.0 | nM | 5.39 |