Assay Detail
Binding
CHEMBL748850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.46 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 6.29 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.00 |
| CHEMBL541398 | — | — | 1 | 5.66 |
| CHEMBL544556 | — | — | 1 | 5.62 |
| CHEMBL536249 | — | — | 1 | 5.58 |
| CHEMBL542065 | — | — | 1 | 5.48 |
| CHEMBL537928 | — | — | 1 | 5.48 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.26 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.12 |
| CHEMBL538467 | — | — | 1 | 5.04 |
| CHEMBL536704 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20835 | ACECLIDINE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL541398 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL544556 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL536249 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL542065 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL537928 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL14 | CARBACHOL | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL550 | PILOCARPINE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL538467 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL536704 | — | IC50 | = | 32000.0 | nM | 4.50 |