Assay Detail
Binding
CHEMBL748898
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Binding affinity against cloned human muscarinic acetylcholine receptor M2.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.00 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418446 | — | — | 1 | 9.05 |
| CHEMBL12098 | SCH-211803 | — | 1 | 9.05 |
| CHEMBL52852 | — | — | 1 | 8.96 |
| CHEMBL421864 | — | — | 1 | 8.80 |
| CHEMBL51256 | — | — | 1 | 8.80 |
| CHEMBL51510 | — | — | 1 | 8.72 |
| CHEMBL51459 | — | — | 1 | 8.68 |
| CHEMBL51096 | — | — | 1 | 8.62 |
| CHEMBL422763 | — | — | 1 | 8.57 |
| CHEMBL417369 | — | — | 1 | 8.30 |
| CHEMBL51400 | — | — | 1 | 8.30 |
| CHEMBL50927 | — | — | 1 | 8.22 |
| CHEMBL49975 | — | — | 1 | 8.15 |
| CHEMBL300845 | — | — | 1 | 8.05 |
| CHEMBL51574 | — | — | 1 | 8.05 |
| CHEMBL50618 | — | — | 1 | 8.05 |
| CHEMBL50998 | — | — | 1 | 7.92 |
| CHEMBL51339 | — | — | 1 | 7.82 |
| CHEMBL52203 | — | — | 1 | 7.77 |
| CHEMBL301354 | — | — | 1 | 7.75 |
| CHEMBL53965 | — | — | 1 | 7.57 |
| CHEMBL51515 | — | — | 1 | 7.46 |
| CHEMBL54155 | — | — | 1 | 7.40 |
| CHEMBL50822 | — | — | 1 | 7.11 |
| CHEMBL50584 | — | — | 1 | 6.98 |
| CHEMBL51982 | — | — | 1 | 6.97 |
| CHEMBL51588 | — | — | 1 | 6.91 |
| CHEMBL53190 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418446 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL12098 | SCH-211803 | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL52852 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL421864 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL51256 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL51510 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL51459 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL51096 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL422763 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL417369 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL51400 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL50927 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL49975 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL300845 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL51574 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL50618 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL50998 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL51339 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL52203 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL301354 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL53965 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL51515 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL54155 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL50822 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL50584 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL51982 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL51588 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL53190 | — | Ki | = | 1300.0 | nM | 5.89 |