Assay Detail
Binding
CHEMBL748901
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Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 9.28 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308566 | — | — | 1 | 9.96 |
| CHEMBL73893 | — | — | 1 | 9.80 |
| CHEMBL71147 | — | — | 1 | 9.77 |
| CHEMBL74117 | — | — | 1 | 9.59 |
| CHEMBL421113 | — | — | 1 | 9.54 |
| CHEMBL440491 | — | — | 1 | 9.52 |
| CHEMBL72408 | — | — | 1 | 9.46 |
| CHEMBL72494 | — | — | 1 | 9.44 |
| CHEMBL72551 | — | — | 1 | 9.42 |
| CHEMBL72363 | — | — | 1 | 9.42 |
| CHEMBL72957 | — | — | 1 | 9.39 |
| CHEMBL70860 | — | — | 1 | 9.35 |
| CHEMBL73245 | — | — | 1 | 9.34 |
| CHEMBL74352 | — | — | 1 | 9.23 |
| CHEMBL307234 | — | — | 1 | 9.00 |
| CHEMBL420008 | — | — | 1 | 8.94 |
| CHEMBL422770 | — | — | 1 | 8.84 |
| CHEMBL70848 | — | — | 1 | 8.66 |
| CHEMBL72787 | — | — | 1 | 8.52 |
| CHEMBL305607 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308566 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL73893 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL71147 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL74117 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL421113 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL440491 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL72408 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL72494 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL72551 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL72363 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL72957 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL70860 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL73245 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL74352 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL307234 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL420008 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL422770 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL70848 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL72787 | — | Ki | = | 2.99 | nM | 8.52 |
| CHEMBL305607 | — | Ki | = | 3.8 | nM | 8.42 |