Assay Detail
Binding
CHEMBL748902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.46 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11892 | — | — | 1 | 9.15 |
| CHEMBL276239 | — | — | 1 | 9.05 |
| CHEMBL12098 | SCH-211803 | — | 1 | 9.05 |
| CHEMBL11756 | — | — | 1 | 9.00 |
| CHEMBL418530 | — | — | 1 | 8.57 |
| CHEMBL12354 | — | — | 1 | 8.37 |
| CHEMBL11527 | — | — | 1 | 8.21 |
| CHEMBL12153 | — | — | 1 | 8.07 |
| CHEMBL12542 | — | — | 1 | 7.96 |
| CHEMBL11816 | — | — | 1 | 7.92 |
| CHEMBL12064 | — | — | 1 | 7.85 |
| CHEMBL12150 | — | — | 1 | 7.77 |
| CHEMBL12085 | — | — | 1 | 7.75 |
| CHEMBL11794 | — | — | 1 | 7.70 |
| CHEMBL12228 | — | — | 1 | 7.70 |
| CHEMBL440601 | — | — | 1 | 7.66 |
| CHEMBL11893 | — | — | 1 | 7.66 |
| CHEMBL275347 | — | — | 1 | 7.58 |
| CHEMBL11690 | — | — | 1 | 7.40 |
| CHEMBL12419 | — | — | 1 | 7.32 |
| CHEMBL412421 | — | — | 1 | 6.98 |
| CHEMBL12215 | — | — | 1 | 6.97 |
| CHEMBL415975 | — | — | 1 | 6.89 |
| CHEMBL12115 | — | — | 1 | 6.87 |
| CHEMBL269645 | — | — | 1 | 6.87 |
| CHEMBL11856 | — | — | 1 | 6.72 |
| CHEMBL274999 | — | — | 1 | 6.62 |
| CHEMBL273439 | — | — | 1 | 6.62 |
| CHEMBL11877 | — | — | 1 | 6.60 |
| CHEMBL12112 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11892 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL276239 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL12098 | SCH-211803 | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL11756 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL418530 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL12354 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL11527 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL12153 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL12542 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL11816 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL12064 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL12150 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL12085 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL11794 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL12228 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL440601 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL11893 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL275347 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL11690 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL12419 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL412421 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL12215 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL415975 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL12115 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL269645 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL11856 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL274999 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL273439 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL11877 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL12112 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL12268 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL12029 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL12291 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL11947 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL11710 | — | Ki | = | 1500.0 | nM | 5.82 |