Assay Detail
Binding
CHEMBL748904
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Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.13 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.59 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.70 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.40 |
| CHEMBL978 | METHACHOLINE | 4.0 | 1 | 7.23 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.12 |
| CHEMBL64788 | — | — | 1 | 6.32 |
| CHEMBL294273 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL14 | CARBACHOL | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL7303 | ARECOLINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL978 | METHACHOLINE | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL12587 | MUSCARINE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL64788 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL294273 | — | Ki | = | 2700.0 | nM | 5.57 |