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Assay Detail

CHEMBL748917

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against human Nmt (HsNmt) using 0.5 uM peptide GNAASAR-R-NH2 and 0.5 uM myristoyl-CoA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Peptide N-myristoyltransferase (CHEMBL2096973)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.
Kawasaki K, Masubuchi M, Morikami K, Sogabe S, Aoyama T, Ebiike H, Niizuma S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N.
Bioorg Med Chem Lett (2003) 13 : 87 -91
PubMed 12467623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.16 4.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL173962 1 4.60
CHEMBL355497 1 4.16
CHEMBL170524 1 4.08
CHEMBL171506 1 4.07
CHEMBL173370 1 4.03
CHEMBL422896 1 4.00
CHEMBL355250 1 -
CHEMBL422746 1 -
CHEMBL353541 1 -
CHEMBL170807 1 -
CHEMBL368134 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL173962 IC50 = 25000.0 nM 4.60
CHEMBL355497 IC50 = 69000.0 nM 4.16
CHEMBL170524 IC50 = 83000.0 nM 4.08
CHEMBL171506 IC50 = 85000.0 nM 4.07
CHEMBL173370 IC50 = 94000.0 nM 4.03
CHEMBL422896 IC50 = 99000.0 nM 4.00
CHEMBL355250 IC50 = 340000.0 nM -
CHEMBL422746 IC50 = 130000.0 nM -
CHEMBL353541 IC50 > 430000.0 nM -
CHEMBL170807 IC50 > 480000.0 nM -
CHEMBL368134 IC50 = 280000.0 nM -