Assay Detail
Binding
CHEMBL748919
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Inhibition of human N-myristoyltransferase (NMT)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.73 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286570 | — | — | 1 | 6.38 |
| CHEMBL33289 | — | — | 1 | 6.30 |
| CHEMBL33525 | — | — | 1 | 6.12 |
| CHEMBL34342 | — | — | 1 | 6.10 |
| CHEMBL33664 | — | — | 1 | 6.10 |
| CHEMBL416405 | — | — | 1 | 6.00 |
| CHEMBL33572 | — | — | 1 | 5.94 |
| CHEMBL33856 | — | — | 1 | 5.82 |
| CHEMBL285198 | — | — | 1 | 5.75 |
| CHEMBL285000 | — | — | 1 | 4.28 |
| CHEMBL33668 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286570 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL33289 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL33525 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL34342 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL33664 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL416405 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL33572 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL33856 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL285198 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL285000 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL33668 | — | IC50 | = | 62000.0 | nM | 4.21 |