Assay Detail
Binding
CHEMBL748967
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Binding affinity (high) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-S
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | A9L |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL3733) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.12 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542064 | — | — | 1 | 7.85 |
| CHEMBL277014 | — | — | 1 | 7.68 |
| CHEMBL542559 | — | — | 1 | 7.51 |
| CHEMBL542065 | — | — | 1 | 7.38 |
| CHEMBL21284 | — | — | 1 | 6.86 |
| CHEMBL538467 | — | — | 1 | 6.45 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542064 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL277014 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL542559 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL542065 | — | Ki | = | 41.7 | nM | 7.38 |
| CHEMBL21284 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL538467 | — | Ki | = | 359.0 | nM | 6.45 |
| CHEMBL14 | CARBACHOL | Ki | = | 739.0 | nM | 6.13 |