Assay Detail
Functional
CHEMBL748976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration needed to reduce 50% of farnesylation in NIH3T3 H-ras cell line
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 8.21 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39805 | — | — | 1 | 9.40 |
| CHEMBL41951 | — | — | 1 | 8.92 |
| CHEMBL434396 | — | — | 1 | 8.92 |
| CHEMBL43455 | — | — | 1 | 8.92 |
| CHEMBL288901 | — | — | 1 | 8.82 |
| CHEMBL38438 | — | — | 1 | 8.74 |
| CHEMBL37194 | — | — | 1 | 8.70 |
| CHEMBL290760 | — | — | 1 | 8.70 |
| CHEMBL38616 | — | — | 1 | 8.68 |
| CHEMBL43082 | — | — | 1 | 8.66 |
| CHEMBL288449 | — | — | 1 | 8.46 |
| CHEMBL289844 | — | — | 1 | 8.46 |
| CHEMBL38941 | — | — | 1 | 8.44 |
| CHEMBL38595 | — | — | 1 | 8.43 |
| CHEMBL39096 | — | — | 1 | 8.40 |
| CHEMBL41936 | — | — | 1 | 8.35 |
| CHEMBL41268 | — | — | 1 | 8.22 |
| CHEMBL43631 | — | — | 1 | 8.22 |
| CHEMBL41515 | — | — | 1 | 8.13 |
| CHEMBL39117 | — | — | 1 | 8.00 |
| CHEMBL288838 | — | — | 1 | 7.77 |
| CHEMBL41540 | — | — | 1 | 7.72 |
| CHEMBL432477 | — | — | 1 | 7.70 |
| CHEMBL38615 | — | — | 1 | 7.62 |
| CHEMBL41454 | — | — | 1 | 7.60 |
| CHEMBL288046 | — | — | 1 | 7.54 |
| CHEMBL287729 | — | — | 1 | 7.34 |
| CHEMBL41682 | — | — | 1 | 7.34 |
| CHEMBL290161 | — | — | 1 | 7.06 |
| CHEMBL41748 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39805 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL41951 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL434396 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL43455 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL288901 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL38438 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL37194 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL290760 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL38616 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL43082 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL288449 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL289844 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL38941 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL38595 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL39096 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL41936 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL41268 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL43631 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL41515 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL39117 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL288838 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL41540 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL432477 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL38615 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL41454 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL288046 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL287729 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL41682 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL290161 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL41748 | — | EC50 | = | 110.0 | nM | 6.96 |