Assay Detail
Binding
CHEMBL749013
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Binding affinity was measured against muscarinic (M1) receptor in rat using [3H]pirenzepine as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.08 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61946 | CARAMIPHEN | 2.0 | 1 | 8.92 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 6.65 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61946 | CARAMIPHEN | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2140.0 | nM | 5.67 |