Assay Detail
Binding
CHEMBL749024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]pirenzepine to muscarinic receptor (M1) in rat cortex homogenates
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and biological activity of some tetraamines related to methoctramine and 4-DAMP
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.03 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | — | 1 | 9.23 |
| CHEMBL165220 | — | — | 1 | 8.30 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 8.19 |
| CHEMBL194216 | SPIROTRAMINE | — | 1 | 7.88 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.43 |
| CHEMBL163901 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL165220 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL194216 | SPIROTRAMINE | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL163901 | — | Ki | = | 75.86 | nM | 7.12 |