Assay Detail
Binding
CHEMBL749048
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Inhibition of Rabbit muscle glycogen phosphorylase B.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.36 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99889 | — | — | 1 | 6.30 |
| CHEMBL326611 | — | — | 1 | 6.05 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.00 |
| CHEMBL118643 | — | — | 1 | 5.22 |
| CHEMBL331779 | — | — | 1 | 4.30 |
| CHEMBL118313 | — | — | 1 | 4.30 |
| CHEMBL331056 | — | — | 1 | - |
| CHEMBL422431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99889 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL326611 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL118643 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL331779 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL118313 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL331056 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL422431 | — | IC50 | ~ | 100000.0 | nM | - |