Compound Detail
CHEMBL118643
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Basic Information
| ChEMBL ID | CHEMBL118643 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VCBSWJNDIGSNCL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
411.8
MW (Da)
4.78
ALogP
4
HBA
3
HBD
112.9
PSA (Ų)
0.54
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form CHEMBL3526 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Glycogen phosphorylase, liver form CHEMBL2568 | IC50 | 4.39 | 4.39 | 41000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of Rabbit muscle glycogen phosphorylase B. | 15214781 |
| Glycogen phosphorylase, liver form | IC50 | = | 41000.0 | nM | 4.39 | In vitro inhibition of pig liver Glycogen phosphorylase A. | 15214781 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15214781 | 10.1021/jm031121n | Glycogen phosphorylase, liver form | 1 |
| 15214781 | 10.1021/jm031121n | Glycogen phosphorylase, muscle form | 1 |
Data from ChEMBL 36 via Core Engine