Assay Detail
Binding
CHEMBL749218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant of the drug-Muscarinic acetylcholine receptor complex.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.70 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51405 | — | — | 1 | 7.03 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.03 |
| CHEMBL154778 | — | — | 1 | 5.77 |
| CHEMBL345627 | — | — | 1 | 5.77 |
| CHEMBL48269 | — | — | 1 | 5.37 |
| CHEMBL347387 | — | — | 1 | 5.00 |
| CHEMBL109815 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51405 | — | Kd | = | 93.0 | nM | 7.03 |
| CHEMBL7634 | OXOTREMORINE | Kd | = | 930.0 | nM | 6.03 |
| CHEMBL154778 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL345627 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL48269 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL347387 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL109815 | — | Kd | = | 11500.0 | nM | 4.94 |