Assay Detail
Binding
CHEMBL749227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for muscarinic acetylcholine receptor by measuring displacement of [3H]QNB from guinea pig urinary bladder
39
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 5.72 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 9.70 |
| CHEMBL109405 | — | — | 1 | 7.17 |
| CHEMBL144385 | — | — | 1 | 6.92 |
| CHEMBL359027 | — | — | 1 | 6.62 |
| CHEMBL144693 | — | — | 1 | 6.51 |
| CHEMBL343236 | — | — | 2 | 6.39 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.28 |
| CHEMBL344327 | — | — | 1 | 6.26 |
| CHEMBL144751 | — | — | 1 | 6.24 |
| CHEMBL144435 | — | — | 1 | 6.22 |
| CHEMBL342958 | — | — | 1 | 6.12 |
| CHEMBL341476 | — | — | 1 | 6.07 |
| CHEMBL357444 | — | — | 1 | 6.06 |
| CHEMBL144434 | — | — | 1 | 6.04 |
| CHEMBL125764 | — | — | 1 | 5.82 |
| CHEMBL144580 | — | — | 1 | 5.70 |
| CHEMBL14580 | — | — | 1 | 5.62 |
| CHEMBL144493 | — | — | 1 | 5.43 |
| CHEMBL356321 | — | — | 1 | 5.43 |
| CHEMBL343697 | — | — | 2 | 5.42 |
| CHEMBL145488 | — | — | 1 | 5.37 |
| CHEMBL145081 | — | — | 1 | 5.27 |
| CHEMBL64779 | — | — | 1 | 5.21 |
| CHEMBL145301 | — | — | 1 | 5.16 |
| CHEMBL358505 | — | — | 1 | 5.09 |
| CHEMBL357200 | — | — | 1 | 5.07 |
| CHEMBL343182 | — | — | 2 | 4.96 |
| CHEMBL145533 | — | — | 1 | 4.72 |
| CHEMBL358493 | — | — | 1 | 4.70 |
| CHEMBL423746 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL109405 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL144385 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL359027 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL144693 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL343236 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL344327 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL144751 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL144435 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL342958 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL341476 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL357444 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL144434 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL125764 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL144580 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL14580 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL144493 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL356321 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL343697 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL145488 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL343236 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL343697 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL145081 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL64779 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL145301 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL358505 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL357200 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL343182 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL145533 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL358493 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL423746 | — | Ki | = | 24700.0 | nM | 4.61 |
| CHEMBL357404 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL144247 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL145608 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL144123 | — | Ki | = | - | nM | - |
| CHEMBL343242 | — | Ki | > | 38000.0 | nM | - |
| CHEMBL144737 | — | Ki | > | 58000.0 | nM | - |
| CHEMBL343182 | — | Ki | > | 35000.0 | nM | - |