Assay Detail
Binding
CHEMBL749231
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In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.13 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69306 | — | — | 1 | 7.52 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.48 |
| CHEMBL69305 | — | — | 1 | 7.17 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.12 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.89 |
| CHEMBL304142 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69306 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL7634 | OXOTREMORINE | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL69305 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL14 | CARBACHOL | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL7303 | ARECOLINE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL304142 | — | EC50 | = | 240.0 | nM | 6.62 |