Assay Detail
Binding
CHEMBL749269
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Binding affinity was determined using [3H]-NMS for Muscarinic acetylcholine receptor in SK-N-SH neuroblastoma cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-SH |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.51 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310852 | — | — | 1 | 6.48 |
| CHEMBL1202134 | — | — | 1 | 5.85 |
| CHEMBL1202052 | — | — | 1 | 5.31 |
| CHEMBL11081 | — | — | 1 | 5.30 |
| CHEMBL1202131 | — | — | 1 | 5.17 |
| CHEMBL1202048 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310852 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL1202134 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1202052 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL11081 | — | Ki | = | 4960.0 | nM | 5.30 |
| CHEMBL1202131 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL1202048 | — | Ki | = | 10900.0 | nM | 4.96 |