Assay Detail
Binding
CHEMBL749270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit binding of [3H]QNB to Muscarinic acetylcholine receptor in cultured N4TG1 neuroblastoma cells at 1e-8 to 1e-3 M
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2097162) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Inhibition of muscarinic receptor binding and acetylcholine-induced contraction of guinea pig ileum by analogues of 5'-(isobutylthio)adenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.35 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604771 | — | — | 1 | 4.41 |
| CHEMBL604770 | — | — | 1 | 4.28 |
| CHEMBL13607 | — | — | 1 | - |
| CHEMBL605813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604771 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL604770 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL13607 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL605813 | — | IC50 | = | 1500000.0 | nM | - |