Muscarinic acetylcholine receptor · PROTEIN FAMILY · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q920H4. Use UniProt Q920H4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q920H4 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M5
Review this target as Muscarinic acetylcholine receptor, mapped to UniProt Q920H4. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M5. Sequence length is 532 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor as ChEMBL target CHEMBL2097162, mapped to UniProt Q920H4. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Muscarinic acetylcholine receptor is the right protein anchor across sources, using UniProt Q920H4 as the stable mapping.
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| Preferred Name | Muscarinic acetylcholine receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q920H4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M5 |
| UniProt Accession | Q920H4 |
| Component Type | Protein |
| Sequence Length | 532 aa |
Muscarinic acetylcholine receptor M5
Review this target as Muscarinic acetylcholine receptor, mapped to UniProt Q920H4. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M5. Sequence length is 532 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1908364 | 8.48 | IC50 | 3.3 | Clinical |
| CHEMBL9967 | 6.12 | IC50 | 750.0 | Clinical |
| CHEMBL545131 | 5.05 | IC50 | 8900.0 | Preclinical |
| CHEMBL275528 | 5.04 | Kd | 9100.0 | Clinical |
| CHEMBL23627 | 4.85 | Kd | 14000.0 | Preclinical |
| CHEMBL23436 | 4.82 | Kd | 15000.0 | Preclinical |
| CHEMBL34000 | 4.66 | IC50 | 22000.0 | Preclinical |
| CHEMBL23626 | 4.6 | Kd | 25000.0 | Preclinical |
| CHEMBL33332 | 4.46 | IC50 | 35000.0 | Preclinical |
| CHEMBL604771 | 4.41 | IC50 | 39000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 11 | 8 | 5.4 |
| cell membrane format | 3 | 6 | 4.4 |
| assay format | 1 | 4 | 4.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| organism-based format | 1 | 0 | — |