Compound Detail
CHEMBL1908364
DEXETIMIDE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1908364 |
| Name | DEXETIMIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LQQIVYSCPWCSSD-HSZRJFAPSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
6
Known Names
1
Indications
Molecular Properties
362.5
MW (Da)
3.27
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Parkinson Disease
ATC Classification
N04AA08
dexetimide
Level 1: NERVOUS SYSTEM
Level 2: ANTI-PARKINSON DRUGS
Activity Summary
IC50 1 meas. best 8.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL2097162 | IC50 | 8.48 | 8.48 | 3.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 3.3 | nM | 8.48 | Ability (10 ug/kg) to inhibit binding of [125I]iododexetimide to muscarinic rece... | 2785211 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| 2785211 | 10.1021/jm00125a021 | Muscarinic acetylcholine receptor | 1 |
Data from ChEMBL 36 via Core Engine