Assay Detail
Binding
CHEMBL749271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability (10 ug/kg) to inhibit binding of [125I]iododexetimide to muscarinic receptor in mice
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2097162) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.55 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908364 | DEXETIMIDE | 2.0 | 1 | 8.48 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.12 |
| CHEMBL545131 | BENZETIMIDE HYDROCHLORIDE | -1.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908364 | DEXETIMIDE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL9967 | PIRENZEPINE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL545131 | BENZETIMIDE HYDROCHLORIDE | IC50 | = | 8900.0 | nM | 5.05 |