Assay Detail
Binding
CHEMBL749327
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Compound was evaluated for binding affinity at N-methyl-D-aspartate glutamate receptor using [3H]CPP as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.64 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340591 | — | — | 1 | 4.64 |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | - |
| CHEMBL125440 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340591 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |
| CHEMBL275040 | KAINIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL125440 | — | IC50 | > | 100000.0 | nM | - |