Assay Detail
Functional
CHEMBL749337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism at NMDA receptor by inhibition of depolarizations induced by 40 uM NMDA in rat cortical slice preparation.
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.18 | 4.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72573 | — | — | 1 | 4.24 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 4.21 |
| CHEMBL433294 | — | — | 1 | 4.08 |
| CHEMBL307281 | — | — | 1 | - |
| CHEMBL73356 | — | — | 1 | - |
| CHEMBL71755 | — | — | 3 | - |
| CHEMBL311632 | — | — | 1 | - |
| CHEMBL72413 | — | — | 1 | - |
| CHEMBL73837 | — | — | 1 | - |
| CHEMBL304282 | — | — | 1 | - |
| CHEMBL70937 | — | — | 1 | - |
| CHEMBL422589 | — | — | 1 | - |
| CHEMBL72592 | — | — | 1 | - |
| CHEMBL72544 | — | — | 1 | - |
| CHEMBL306851 | — | — | 1 | - |
| CHEMBL423498 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72573 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL433294 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL307281 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL73356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL311632 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72413 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL304282 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL70937 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL422589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL306851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL73837 | — | IC50 | > | 100000.0 | nM | - |