Assay Detail
Binding
CHEMBL749349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro Binding affinity towards alpha-1-beta-1-gamma-delta nAChR was determined
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Acetylcholine receptor; alpha1/beta1/delta/gamma (CHEMBL1907588) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.05 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111583 | — | — | 1 | 5.52 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111583 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL56564 | TROPISETRON | Ki | = | 27000.0 | nM | 4.57 |