Assay Detail
Binding
CHEMBL749361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards norepinephrine transporter was determined using [3H]nisoxetine radioligand.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.34 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317905 | — | — | 1 | 7.58 |
| CHEMBL103523 | — | — | 1 | 7.28 |
| CHEMBL103227 | — | — | 1 | 7.14 |
| CHEMBL316528 | — | — | 1 | 6.96 |
| CHEMBL103228 | — | — | 1 | 6.82 |
| CHEMBL317904 | — | — | 1 | 6.75 |
| CHEMBL14144 | — | — | 1 | 6.67 |
| CHEMBL298580 | — | — | 1 | 6.66 |
| CHEMBL316585 | — | — | 1 | 6.62 |
| CHEMBL320627 | — | — | 1 | 6.34 |
| CHEMBL322856 | — | — | 1 | 6.34 |
| CHEMBL102279 | — | — | 1 | 6.26 |
| CHEMBL1790051 | — | — | 1 | 6.26 |
| CHEMBL329517 | — | — | 1 | 6.26 |
| CHEMBL321806 | — | — | 1 | 6.26 |
| CHEMBL321780 | — | — | 1 | 6.24 |
| CHEMBL322385 | — | — | 1 | 5.99 |
| CHEMBL322400 | — | — | 1 | 5.81 |
| CHEMBL317909 | — | — | 1 | 5.74 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.70 |
| CHEMBL100652 | — | — | 1 | 5.42 |
| CHEMBL103223 | — | — | 1 | 5.42 |
| CHEMBL328415 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317905 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL103523 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL103227 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL316528 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL103228 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL317904 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL14144 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL298580 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL316585 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL320627 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL322856 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL102279 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL1790051 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL329517 | — | Ki | = | 553.0 | nM | 6.26 |
| CHEMBL321806 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL321780 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL322385 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL322400 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL317909 | — | Ki | = | 1825.0 | nM | 5.74 |
| CHEMBL370805 | COCAINE | Ki | = | 1990.0 | nM | 5.70 |
| CHEMBL100652 | — | Ki | = | 3807.0 | nM | 5.42 |
| CHEMBL103223 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL328415 | — | Ki | = | 3990.0 | nM | 5.40 |