Assay Detail
Binding
CHEMBL749385
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Ability to compete with [3H]CCP for rat cortical and hippocampal membrane glutamate binding site.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.44 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 4.92 |
| CHEMBL51196 | — | — | 1 | 4.80 |
| CHEMBL417544 | — | — | 1 | 4.60 |
| CHEMBL278097 | — | — | 1 | 4.47 |
| CHEMBL54120 | — | — | 1 | 4.29 |
| CHEMBL50160 | — | — | 1 | 4.22 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.15 |
| CHEMBL300949 | — | — | 1 | 4.06 |
| CHEMBL31344 | — | — | 1 | - |
| CHEMBL295718 | — | — | 1 | - |
| CHEMBL301556 | — | — | 1 | - |
| CHEMBL53744 | — | — | 1 | - |
| CHEMBL298643 | — | — | 1 | - |
| CHEMBL50502 | — | — | 1 | - |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL50744 | — | — | 1 | - |
| CHEMBL298929 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL51196 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL417544 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL278097 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL54120 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL50160 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL299155 | TRANSTORINE | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL300949 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL31344 | — | IC50 | = | 358000.0 | nM | - |
| CHEMBL295718 | — | IC50 | = | 283000.0 | nM | - |
| CHEMBL301556 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL53744 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL298643 | — | IC50 | = | 710000.0 | nM | - |
| CHEMBL50502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | IC50 | = | 4200000.0 | nM | - |
| CHEMBL50744 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298929 | — | IC50 | = | 141000.0 | nM | - |