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Assay Detail

CHEMBL749398

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of phorbol-12-myristate-13-acetate (PMA)induced superoxide burst in human neutrophils
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits.
Lampe JW, Biggers CK, Defauw JM, Foglesong RJ, Hall SE, Heerding JM, Hollinshead SP, Hu H, Hughes PF, Jagdmann GE, Johnson MG, Lai YS, Lowden CT, Lynch MP, Mendoza JS, Murphy MM, Wilson JW, Ballas LM, Carter K, Darges JW, Davis JE, Hubbard FR, Stamper ML.
J Med Chem (2002) 45 : 2624 -2643
PubMed 12036372 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.44 6.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL91126 1 6.33
CHEMBL89639 1 5.82
CHEMBL328747 1 5.04
CHEMBL88749 1 5.00
CHEMBL89591 1 5.00
CHEMBL312846 1 -
CHEMBL89384 1 -
CHEMBL89648 1 -
CHEMBL421539 1 -
CHEMBL433361 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL91126 IC50 = 470.0 nM 6.33
CHEMBL89639 IC50 = 1500.0 nM 5.82
CHEMBL328747 IC50 = 9200.0 nM 5.04
CHEMBL88749 IC50 = 10000.0 nM 5.00
CHEMBL89591 IC50 = 10000.0 nM 5.00
CHEMBL312846 IC50 > 10000.0 nM -
CHEMBL89384 IC50 > 10000.0 nM -
CHEMBL89648 IC50 > 10000.0 nM -
CHEMBL421539 IC50 > 10000.0 nM -
CHEMBL433361 IC50 > 10000.0 nM -