Assay Detail
Functional
CHEMBL749433
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Effective concentration against anchorage-independent growth of H-ras-transformed NIH3T3 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.62 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312598 | — | — | 1 | 6.72 |
| CHEMBL75237 | — | — | 1 | 6.39 |
| CHEMBL74363 | — | — | 1 | 6.30 |
| CHEMBL73862 | — | — | 1 | 6.24 |
| CHEMBL77419 | — | — | 1 | 6.00 |
| CHEMBL306294 | — | — | 1 | 5.75 |
| CHEMBL75677 | — | — | 1 | 5.70 |
| CHEMBL310413 | — | — | 1 | 5.30 |
| CHEMBL308724 | — | — | 1 | 5.30 |
| CHEMBL309188 | — | — | 1 | 5.08 |
| CHEMBL310863 | — | — | 1 | 4.82 |
| CHEMBL311710 | — | — | 1 | 4.82 |
| CHEMBL75804 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312598 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL75237 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL74363 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL73862 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL77419 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL306294 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL75677 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL310413 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL308724 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL309188 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL310863 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL311710 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL75804 | — | EC50 | = | 26000.0 | nM | 4.58 |