Assay Detail
Binding
CHEMBL749480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.05 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553451 | — | — | 1 | 8.61 |
| CHEMBL553554 | — | — | 1 | 8.60 |
| CHEMBL539021 | — | — | 1 | 8.51 |
| CHEMBL554092 | — | — | 1 | 8.40 |
| CHEMBL553617 | — | — | 1 | 8.40 |
| CHEMBL540553 | — | — | 1 | 8.36 |
| CHEMBL315814 | — | — | 1 | 8.35 |
| CHEMBL315923 | — | — | 1 | 8.31 |
| CHEMBL82386 | — | — | 1 | 8.23 |
| CHEMBL432183 | — | — | 1 | 8.12 |
| CHEMBL314119 | — | — | 1 | 8.09 |
| CHEMBL315982 | — | — | 1 | 8.07 |
| CHEMBL312173 | — | — | 1 | 8.06 |
| CHEMBL313931 | — | — | 1 | 8.06 |
| CHEMBL310173 | — | — | 1 | 8.01 |
| CHEMBL83585 | — | — | 1 | 7.97 |
| CHEMBL313546 | — | — | 1 | 7.87 |
| CHEMBL84055 | — | — | 1 | 7.63 |
| CHEMBL315322 | — | — | 1 | 7.63 |
| CHEMBL85499 | — | — | 1 | 7.43 |
| CHEMBL83885 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553451 | — | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL553554 | — | IC50 | = | 2.49 | nM | 8.60 |
| CHEMBL539021 | — | IC50 | = | 3.11 | nM | 8.51 |
| CHEMBL554092 | — | IC50 | = | 4.01 | nM | 8.40 |
| CHEMBL553617 | — | IC50 | = | 3.94 | nM | 8.40 |
| CHEMBL540553 | — | IC50 | = | 4.34 | nM | 8.36 |
| CHEMBL315814 | — | IC50 | = | 4.51 | nM | 8.35 |
| CHEMBL315923 | — | IC50 | = | 4.88 | nM | 8.31 |
| CHEMBL82386 | — | IC50 | = | 5.88 | nM | 8.23 |
| CHEMBL432183 | — | IC50 | = | 7.53 | nM | 8.12 |
| CHEMBL314119 | — | IC50 | = | 8.14 | nM | 8.09 |
| CHEMBL315982 | — | IC50 | = | 8.49 | nM | 8.07 |
| CHEMBL312173 | — | IC50 | = | 8.62 | nM | 8.06 |
| CHEMBL313931 | — | IC50 | = | 8.72 | nM | 8.06 |
| CHEMBL310173 | — | IC50 | = | 9.76 | nM | 8.01 |
| CHEMBL83585 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL313546 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL84055 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL315322 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL85499 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL83885 | — | IC50 | = | 567.0 | nM | 6.25 |