Assay Detail
Functional
CHEMBL749619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Complete inhibition of cell growth of 60-human tumor cell line detected by National Cancer Institute.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of antineoplastic agents based on the "2-phenylnaphthalene-type" structural pattern. 4. Synthesis and biological activity of 2-chloro-3-(substituted phenoxy)-1, 4-naphthoquinones and related 5,8-dihydroxy-1,4-naphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.20 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133389 | — | — | 1 | 7.00 |
| CHEMBL131549 | — | — | 1 | 7.00 |
| CHEMBL133394 | — | — | 1 | 7.00 |
| CHEMBL422982 | — | — | 1 | 7.00 |
| CHEMBL130001 | — | — | 1 | 6.00 |
| CHEMBL335159 | — | — | 1 | 6.00 |
| CHEMBL130836 | — | — | 1 | 6.00 |
| CHEMBL129941 | — | — | 1 | 6.00 |
| CHEMBL132613 | — | — | 1 | 6.00 |
| CHEMBL130385 | — | — | 1 | 6.00 |
| CHEMBL130862 | — | — | 1 | 6.00 |
| CHEMBL132829 | — | — | 1 | 6.00 |
| CHEMBL130408 | — | — | 1 | 6.00 |
| CHEMBL133181 | — | — | 1 | 6.00 |
| CHEMBL131038 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133389 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131549 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL133394 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL422982 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130001 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL335159 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL130836 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL129941 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL132613 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL130385 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL130862 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL132829 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL130408 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL133181 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL131038 | — | IC50 | = | 10000.0 | nM | 5.00 |