Assay Detail
Functional
CHEMBL749697
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T24H-ras-transformed NIH3T3 cell proliferation
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.48 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.77 |
| CHEMBL341586 | — | — | 3 | 8.00 |
| CHEMBL343998 | — | — | 1 | 7.76 |
| CHEMBL337751 | — | — | 3 | 7.70 |
| CHEMBL335609 | — | — | 1 | 7.55 |
| CHEMBL136633 | — | — | 1 | 7.06 |
| CHEMBL140139 | — | — | 1 | 6.73 |
| CHEMBL343060 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL341586 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL341586 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL343998 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL337751 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL335609 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL337751 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL136633 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL341586 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL140139 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL343060 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL337751 | — | IC50 | > | 500.0 | nM | - |