Assay Detail
Binding
CHEMBL749823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against N-methyl-D-aspartate glutamate receptor 2B in rat
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL311) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.17 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108043 | — | — | 1 | 5.33 |
| CHEMBL107193 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108043 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL107193 | — | IC50 | = | 10000.0 | nM | 5.00 |