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Assay Detail

CHEMBL749825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Peptide N-myristoyltransferase (CHEMBL2096973)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.
Kawasaki K, Masubuchi M, Morikami K, Sogabe S, Aoyama T, Ebiike H, Niizuma S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N.
Bioorg Med Chem Lett (2003) 13 : 87 -91
PubMed 12467623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.46 8.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL355250 1 8.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL355250 IC50 = 3.5 nM 8.46