Assay Detail
Binding
CHEMBL749827
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In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aspergillus fumigatus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.96 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422896 | — | — | 1 | 6.32 |
| CHEMBL170524 | — | — | 1 | 5.37 |
| CHEMBL171506 | — | — | 1 | 5.29 |
| CHEMBL353541 | — | — | 1 | 4.96 |
| CHEMBL173370 | — | — | 1 | 4.89 |
| CHEMBL422746 | — | — | 1 | 4.75 |
| CHEMBL355497 | — | — | 1 | 4.52 |
| CHEMBL355250 | — | — | 1 | 4.38 |
| CHEMBL173962 | — | — | 1 | 4.20 |
| CHEMBL368134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422896 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL170524 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL171506 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL353541 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL173370 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL422746 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL355497 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL355250 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL173962 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL368134 | — | IC50 | = | 150000.0 | nM | - |