Assay Detail
Binding
CHEMBL749841
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Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.95 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | 3.0 | 1 | 8.80 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.52 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL59 | DOPAMINE | IC50 | = | 3045.0 | nM | 5.52 |